Rintaro suffering from the disease's effects.

Henisei Tashu Ijō Syndrome(変異性多種異常症候群), or better known as the Hentai Syndrome(変多異症), is an extremely rare disease that causes the heart to be placed under immense stress if the carrier becomes sexually aroused. Due to the limited amount of medical knowledge on the topic, the only way to avoid the disease's lethal effects is to live a life without sexual stimuli. Currently Rintaro is the only known person to carry the disease, and was diagnosed at the age of six.[1]


  1. Dragons Rioting manga; Chapter 1, page 6-8

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